CAS
No.: 292618-32-7
Molecular
Formula: C25H25N3O5
Molecular
Weight: 447.48
Appearance:
White powder
Gimatecan
is an orally bioavailable, semi-synthetic lipophilic alternation of
camptothecin, a quinoline alkaloid extracted from the Asian timberline
Camptotheca acuminate, with abeyant antineoplastic and antiangiogenic
activities. Gimatecan binds to and inhibits the action of topoisomerase I,
stabilizing the cleavable circuitous of topoisomerase I-DNA, which inhibits the
religation of single-stranded DNA break generated by topoisomerase I; baleful
double-stranded DNA break action if the topoisomerase I-DNA circuitous is
encountered by the DNA archetype machinery, DNA archetype is disrupted, and the
bump corpuscle undergoes apoptosis. Although the apparatus of its
antiangiogenic action has yet to be abounding elucidated, this abettor may
arrest endothelial corpuscle migration, bump neovascularization, and the
announcement of proangiogenic basal fibroblast advance agency (bFGF).
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