CAS
No.: 130-26-7
Molecular
Formula: C9H5ClINO
Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated
8-hydroxyquinoline with antifungal, antiparasitic and abeyant antitumor
activities. Clioquinol forms a abiding chelate with chestnut (copper (II)
ions), which inhibits the chymotrypsin-like action of the proteasome;
consequently, ubiquitinated proteins may accrue in bump cells, followed by bump
corpuscle apoptosis and the inhibition of bump angiogenesis.
In
addition, the clioquinol-copper circuitous appears to abatement the
announcement of androgen receptors (AR) in animal copper-enriched prostate
blight cells. Serum levels of chestnut are generally animated in patients with
cancer; chestnut chelation may arrest copper-dependent endothelial corpuscle
admeasurement and bump beard of angiogenic factors.
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