Ramoplanin Description

Ramoplanin is a atypical glycolipodepsipeptide antibacterial beneath development for the analysis of CDAD.

Ramoplanin represents a new chic of antibiotics with a atypical apparatus of activity that is awful able adjoin Staphylococci.

Ramoplanin is the aboriginal in a new chic of antimicrobials to ability analytic trials. It is a glycolipodepsipeptide produced by the beverage of Actinoplanes spp.. Ramoplanin blocks bacterial corpuscle bank biosynthesis by interfering with peptidoglycan production. Ramoplanin inhibits the N-acetylglucosaminyltransferase-catalysed about-face of lipid average I to lipid average II, a footfall that occurs afore the transglycosylation and transpeptidation reactions. Ramoplanin’s apparatus of activity is audible from that of glycopeptides. Unlike glycopeptides, ramoplanin does not circuitous with the D-Ala–D-Ala arrangement of corpuscle bank precursors.