Pergolide Pharmacology

Pergolide (trade names Permax, Prascend) is an ergoline-based dopamine receptor agonist acclimated in some countries for the analysis of Parkinson's disease.

Pergolide acts as an agonist of dopamine D2 and D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may acquire agonist action at added dopamine receptor subtypes as well, agnate to cabergoline. Although pergolide is added almighty as an agonist of the D2 receptor, it has top D1 receptor affection and is one of the a lot of almighty D1 receptor agonists of the dopamine receptor agonists that are clinically available. The agonist action of pergolide at the D1 receptor somewhat alters its analytic and ancillary aftereffect contour in the analysis of Parkinson's disease.