Morpholine organic synthesis use

Morpholine undergoes a lot of actinic reactions archetypal for added accessory amines, admitting the attendance of the ether oxygen withdraws electron body from the nitrogen, apprehension it beneath nucleophilic (and beneath basic) than structurally agnate accessory amines such as piperidine. For this reason, it forms a abiding chloramine.

It is frequently used to accomplish enamines.

Morpholine is broadly used in amoebic synthesis. For example, it is a architecture block in the alertness of the antibacterial linezolid, the anticancer abettor gefitinib (Iressa) and the analgesic dextromoramide.

In analysis and in industry, the low amount and polarity of morpholine advance to its accepted use as a bread-and-butter for actinic reactions.